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The SENTINEL Project

SENTINEL Plus is based on the SENTINEL project, an on-going quality improvement initiative undertaken in Hull and East Yorkshire, supported through a Joint Working Agreement between Hull University Teaching Hospitals NHS Trust and AstraZeneca UK.

The SENTINEL project developed an intervention to implement the local asthma guideline which has a focus on reducing short-acting beta agonist (SABA) over-reliance and using Maintenance and Reliever Therapy (MART) for appropriate patients.

The intervention was designed in collaboration with asthma clinicians and patients using experience based co-design methodology, and includes the 5 core elements detailed on the right to support sustained improvements in asthma care.

The 5 core elements aim to support sustained improvements in asthma care.

Pilot data from the SENTINEL project has demonstrated that implementation of a MART focussed asthma guideline can substantially reduce SABA prescribing and reduce the proportion of all inhaled therapies that are a SABA. This data was presented at the European Respiratory Society Conference 2021. 1,2

A detailed evaluation is on-going as the intervention continues to expand to additional primary care networks (PCNs) within Hull and East Yorkshire as part of the SENTINEL project.


  1. Crooks, M et al. Impact of maintenance and reliever therapy (MART) focussed asthma guideline on SABA prescriptions. Abstract presented at European Respiratory Society (ERS) International Congress, 2021; Sep 5-8: Abstract no. OA80
  2. Open Prescribing. Available from (Accessed 5th October 2021)

This website is part of the SENTINEL Plus quality improvement package which has been funded by AstraZeneca and co-developed with Hull York Medical School and Hull University Teaching Hospitals NHS Trust.

This website is intended for UK Healthcare Professionals.

GB-32724 - Date of Preparation, November 2021. Copyright © University of Hull 2021
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GB-33203. Date of Preparation: November 2021

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